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Structural Basis for the Formation of PTPRG•CNTN Complexes in Neural Tissues
(2016)
Receptor protein tyrosine phosphatase gamma (PTPRG) is a cell surface receptor expressed primarily on neurons. It combines cytoplasmic tyrosine phosphatase domains and an extracellular region that includes a carbonic ...
The Ins and Outs and ABCs of Antifungal Drug Transport: Characterizing the Role of Membrane Transporters in Pathogenic Fungi
(2016)
Pathogenic fungi cause serious disease and even death in humans, animals and plants. In medicine and agriculture alike, fungal infections are widespread and represent a significant threat to global public health. The ...
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an
enormous amount of information is being generated regarding the structural, biochemical and
physiological aspects of proteins. Tertiary ...
Identification and Characterization of Two Novel Sleep Promoting Neurons Located in the Ventral Nerve Cord of Drosophila Melanogaster
(2023)
Sleep is a phenomenon that is ubiquitous in the animal kingdom and can be found in nearly every evolutionary niche that has come about. Humans cannot live without it, and it is required for optimal physical and mental ...
Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
(University of Missouri -- Kansas City, 2017)
FK506 binding-like proteins (FKBPLs) are proteins that structurally resemble the
immunophilins. Their functions in cell signaling include protein folding, molecular trafficking,
RNA splicing and cell cycle regulation ...